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Invitrogen
HTR2B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-33303
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from 2nd extracellular domain of human 5HT2B Receptor.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is not recommended for use in ICC applications.
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%) Bovine, Bat (93%).
靶标信息
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-HT 2B receptor; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5HT2B Receptor; serotonin; serotonin receptor 2B; unnamed protein product
基因别名: 5-HT(2B); 5-HT-2B; 5-HT2B
UniProt ID: (Human) P41595
Entrez Gene ID: (Human) 3357
neural crest cell migration
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
heart morphogenesis
cardiac muscle hypertrophy
cellular calcium ion homeostasis
smooth muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
heart development
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of phosphatidylinositol biosynthetic process
neural crest cell differentiation
intestine smooth muscle contraction
calcium-mediated signaling
vasoconstriction
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
embryonic morphogenesis
regulation of behavior
release of sequestered calcium ion into cytosol
positive regulation of cell division
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
