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Invitrogen
HUS1 Polyclonal Antibody
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HUS1 Antibody (PA5-102763) in ICC/IF
Immunocytochemistry analysis of HUS1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with HUS1 polyclonal antibody (Product # PA5-102763) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-102763
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HUS1(Accession O60921), corresponding to amino acid residues E189-Q239.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total HUS1.
靶标信息
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Checkpoint protein HUS1; hHUS1; HUS1 checkpoint homolog; Hus1 homolog; HUS1 protein; hus1+-like protein; mHUS1
基因别名: hHUS1; HUS1
UniProt ID: (Human) O60921, (Mouse) Q8BQY8
Entrez Gene ID: (Human) 3364, (Rat) 498411, (Mouse) 15574
DNA damage checkpoint
double-strand break repair via homologous recombination
regulation of protein phosphorylation
DNA replication
DNA repair
nucleotide-excision repair
protein phosphorylation
cellular response to DNA damage stimulus
negative regulation of DNA replication
response to UV
embryo development
intra-S DNA damage checkpoint
mitotic DNA replication checkpoint
meiotic DNA integrity checkpoint
cellular response to ionizing radiation
regulation of signal transduction by p53 class mediator
mitotic cell cycle checkpoint
