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Invitrogen
HYAL2 Polyclonal Antibody
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HYAL2 Antibody (PA5-95061) in WB
Western blot analysis of HYAL2 in Lane 1: HeLa whole cell lysate (40 µg), Lane 2: SMMC whole cell lysate (40 µg), Lane 3: COLO320 whole cell lysate (40 µg), Lane 4: MCF-7 whole cell lysate (40 µg), Lane 5: HT1080 whole cell lysate (40 µg). Samples were incubated with HYAL2 polyclonal antibody (Product # PA5-95061).
产品信息
PA5-95061
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2 (142-157aa VRNWQDKDVYRRLSRQ).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, SMMC whole cell, COLO320 whole cell, MCF-7 whole cell, HT1080 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hyal-2; Hyaluronidase; hyaluronidase 2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog
基因别名: AI256841; AU020858; AW555733; HYAL2; LUCA2
UniProt ID: (Human) Q12891, (Mouse) O35632
Entrez Gene ID: (Human) 8692, (Rat) 64468, (Mouse) 15587
RNA polymerase II transcription coactivator activity
virus receptor activity
hyalurononglucosaminidase activity
protein binding
hyaluronic acid binding
enzyme binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
hyaluronoglucuronidase activity
transforming growth factor beta binding
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
glycosidase
response to reactive oxygen species
kidney development
hematopoietic progenitor cell differentiation
carbohydrate metabolic process
glycosaminoglycan catabolic process
response to virus
multicellular organism aging
negative regulation of fibroblast migration
fusion of virus membrane with host plasma membrane
transformation of host cell by virus
hyaluronan catabolic process
negative regulation of cell growth
positive regulation of urine volume
monocyte activation
positive regulation of protein import into nucleus
negative regulation of MAP kinase activity
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
viral entry into host cell
skeletal system morphogenesis
positive regulation of inflammatory response
cartilage development
defense response to virus
negative regulation of protein kinase B signaling
multicellular organismal iron ion homeostasis
negative regulation of protein tyrosine kinase activity
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to UV-B
cellular response to transforming growth factor beta stimulus
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
positive regulation of extrinsic apoptotic signaling pathway
metabolic process
