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Abnova
HYPE Monoclonal Antibody (3F5)
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产品信息
H00011153-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3F5
抗原
HYPE (AAH01342, 1 a.a. approximately 449 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAVTEPKWVS VWSRFLWVTL LSMVLGSLLA LLLPLGAVEE QCLAVLKGLY LLRSKPDRAQ HAATKCTSPS TELSITSRGA TLLVAKTKAS PAGKLEARAA LNQALEMKRQ GKREKAQKLF MHALKMDPDF VDALTEFGIF SEEDKDIIQA DYLYTRALTI SPYHEKALVN RDRTLPLVEE IDQRYFSIID SKVKKVMSIP KGNSALRRVM EETYYHHIYH TVAIEGNTLT LSEIRHILET RYAVPGKSLE EQNEVIGMHA AMKYINTTLV SRIGSVTISD VLEIHRRVLG YVDPVEAGRF RTTQVLVGHH IPPHPQDVEK QMQEFVQWLN SEEAMNLHPV EFAALAHYKL VYIHPFIDGN GRTSRLLMNL ILMQAGYPPI TIRKEQRSDY YHVLEAANEG DVRPFIRFIA KCTETTLDTL LFATTEYSVA LPEAQPNHSG FKETLPVKP
靶标信息
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMPylator FICD; De-AMPylase FICD; FIC domain-containing protein; fic S-phase protein cell division homolog; HIP-13; huntingtin interacting protein 13; Huntingtin interacting protein E; huntingtin interactor protein E; Huntingtin yeast partner E; Huntingtin-interacting protein 13; Huntingtin-interacting protein E; MGC5623; Protein adenylyltransferase FICD
基因别名: FICD; HIP13; HYPE; UNQ3041; UNQ3041/PRO9857
UniProt ID: (Human) Q9BVA6
Entrez Gene ID: (Human) 11153
