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Invitrogen
Halofuginone Recombinant Mouse Monoclonal Antibody (2F9)
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Halofuginone Antibody (MA566468) in SDS-PAGE
SDS-PAGE characterization of Halofuginone under reducing conditions. Lane M: Protein marker (kDa); Lane HAL: Purified Halofuginone Recombinant Monoclonal (Product # MA566468). Halofuginone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-439.
产品信息
MA566468
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2F9
抗原
Conjugate of HAL hapten and KLH.
偶联物
形式
Liquid
浓度
3.8 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Halofuginone is a derivative of febrifugine, an alkaloid originally isolated from the plant Dichroa febrifuga. It is used in veterinary medicine to prevent and treat protozoan diseases such as coccidiosis in poultry and cryptosporidiosis in calves. Halofuginone acts as a potent inhibitor of collagen alpha 1 (I) and matrix metalloproteinase 2 (MMP-2) gene expression, suppressing extracellular matrix deposition and cell proliferation. Its therapeutic applications extend to treating malaria, cancer, fibrosis, and inflammatory diseases, owing to its ability to inhibit prolyl-tRNA synthetase, a molecular target involved in these conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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