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Abnova
Hmox1 Recombinant Rabbit Monoclonal Antibody
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Hmox1 Antibody (RAB02434) in ICC/IF
Immunofluorescent analysis of U87MG cells with HO-1 recombinant monoclonal antibody (Product # RAB02434). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humified chamber. Cells were washed with PBST and incubated with a AF488-conjugated secondary antibody (green) in PBS at room temperature in the dark.
产品信息
RAB02434
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 50% glycerol, 150mM NaCl
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: heme orygenase 1; heme oxygenase (decycling) 1; Heme oxygenase 1; hemoxygenase; HO-1; P32 protein
基因别名: D8Wsu38e; Hemox; Hmox; Hmox1; HO-1; HO1; Hsp32
UniProt ID: (Mouse) P14901
Entrez Gene ID: (Mouse) 15368
angiogenesis
wound healing involved in inflammatory response
heme oxidation
cellular iron ion homeostasis
apoptotic process
response to oxidative stress
small GTPase mediated signal transduction
regulation of blood pressure
cell death
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of muscle cell apoptotic process
negative regulation of mast cell cytokine production
erythrocyte homeostasis
regulation of transcription from RNA polymerase II promoter in response to iron
cellular response to heat
response to nicotine
intracellular signal transduction
heme catabolic process
heme metabolic process
response to hydrogen peroxide
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of mast cell degranulation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
response to estrogen
positive regulation of angiogenesis
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
protein homooligomerization
iron ion homeostasis
oxidation-reduction process
cellular response to arsenic-containing substance
cellular response to cadmium ion
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
