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Invitrogen
Hyaluronic acid Polyclonal Antibody
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产品信息
PA1-85561
产品规格
种属反应
Chemical
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Hyaluronic acid from human umbilical cord.
偶联物
形式
Liquid
浓度
5 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
For direct ELISA, coat wells with 1% glutaraldehyde for 5 min at room temperature, followed by 3xPBS wash steps prior to coating with hyaluronic acid.
Sheep anti hyaluronic acid antibody recognizes hyaluronic acid, a mucopolysaccharide which is an integral part of the gel-like substance of animal connective tissue that serves as a lubricating and protective agent.
靶标信息
Hyaluronic acid (HA), is the most abundant glycosaminoglycan (GAG) in mammalian tissue. It is present in high concentrations in connective tissue, such as skin, vitreous humor, cartilage, and umbilical cord, but the largest single reservoir is the synovial fluid (SF) of the diarthrodial joints, where concentrations of 0. 5-4 mg/mL are achieved. Hyaluronic acid, is the major hydrodynamic nonprotein component of joint SF. Its unique viscoelastic properties confer remarkable shock absorbing and lubricating abilities to SF, while its enormous macromolecular size and hydrophilicity serve to retain fluid in the joint cavity during articulation. HA restricts the entry of large plasma proteins and cells into SF but facilitates solute exchange between the synovial capillaries and cartilage and other joint tissues. In addition, HA can form a pericellular coat around cells, interact with proinflammatory mediators, and bind to cell receptors, such as cluster determinant (CD)44 and receptor for hyaluronate-mediated motility (RHAMM), where it modulates cell proliferation, migration, and gene expression. All these physicochemical and biologic properties of HA have been shown to be molecular weight (MW) dependent. The diverse physicochemical properties of HA arise from its unique macromolecular structure. The HA is an exceptionally long (3-30 µm) and unbranched nonsulfated GAG composed of repeating disaccharide units of N-acetylglucosamine, and glucuronic acid glycosidically linked through their respective 1-4 ring positions. Hydroxyl group oxygens at the glucuronyl-1 and glucosamine 3-positions are used for further polymerization of the HA disaccharide units to form chains that, when released from the cell plasma membrane, are of variable length and thus polydispersity. Despite the simplicity of the HA primary structure, this linear polyelectrolyte adopts complex conformations in solution, which engender it with diverse biologic properties. Within the joint cavity, HA molecules are predominately synthesized by the type B synovial cells. (PMID: 12219318). [National Center for Biotechnology Information. PubChem Compound Database; CID=24728612].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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