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Invitrogen
Hydrochlorothiazide Recombinant Mouse Monoclonal Antibody (7G9)
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Hydrochlorothiazide Antibody (MA566463) in SDS-PAGE
SDS-PAGE characterization of Hydrochlorothiazide under reducing conditions. Lane M: Protein marker (kDa); Lane DCT: Purified Hydrochlorothiazide Recombinant Monoclonal (Product # MA566463). Hydrochlorothiazide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-627.
产品信息
MA566463
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7G9
抗原
Conjugate of DCT hapten and KLH.
偶联物
形式
Liquid
浓度
4.7 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Hydrochlorothiazide (HCTZ) is a commonly used thiazide diuretic that helps manage hypertension (high blood pressure) and edema associated with congestive heart failure, liver cirrhosis, and renal disorders. Its primary mechanism involves inhibiting the sodium-chloride symporter in the distal convoluted tubules of the kidney, leading to increased excretion of sodium and water. This diuretic effect decreases plasma volume, resulting in reduced cardiac output and blood pressure. Hydrochlorothiazide also mildly affects calcium excretion, offering additional benefits in reducing the risk of calcium-containing kidney stones. Due to its antihypertensive properties, HCTZ is often prescribed alone or in combination with other antihypertensive agents, such as ACE inhibitors or angiotensin II receptor blockers. While generally well-tolerated, potential side effects include electrolyte imbalances (such as hypokalemia), dehydration, hyperglycemia, and increased uric acid levels, which may exacerbate gout. Regular monitoring of renal function and electrolytes is recommended during treatment. Hydrochlorothiazide's role in managing hypertension highlights its importance as a foundational therapy in cardiovascular disease management.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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