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Invitrogen
Hydromorphone Polyclonal Antibody
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产品信息
PA1-75167
产品规格
种属反应
Chemical
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Hydromorphone(3)-BTG
偶联物
形式
Liquid
浓度
7.28 mg/mL
纯化类型
purified
保存液
PBS, pH 7.8
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Working Concentration: 1.25 µg/mL. Sensitivity: 10 ng/mL Hydromorphone produces 74% inhibition in a competitive ELISA employing Hydromorphone polyclonal antibody.
靶标信息
Hydromorphone Base is the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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