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Invitrogen
IBA1 Recombinant Rat Monoclonal Antibody (HL22-RT)
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IBA1 Antibody (MA5-38266) in IHC (P)
Immunohistochemical analysis of IBA1 was performed using formalin-fixed paraffin-embedded human brain tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. Follo... View More
产品信息
MA5-38266
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rat
/ IgG1
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL22-RT
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Iba1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Centrifuge briefly prior to opening.
靶标信息
Ionized calcium-binding adapter molecule 1 (IBA1), also known by its gene name AIF1, is a protein expressed predominantly by microglia in the brain and spinal cord. This protein belongs to the EF-hand calcium-binding protein family and plays a crucial role in microglial activation and migration in response to brain injury or neuroinflammation. IBA1's function is integral to microglial motility and phagocytic activity, facilitating the cellular response to pathogenic stimuli and promoting tissue homeostasis and repair in the central nervous system. IBA1 serves as a reliable marker for activated microglia in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where increased expression correlates with disease progression and severity. The protein's structural features enable it to bind calcium ions, inducing conformational changes that activate signaling pathways essential for microglial function. Its expression is highly regulated by inflammatory cytokines, underpinning its role in neuroimmune responses. Due to its specific expression in microglia during pathological conditions, IBA1 is widely used in research as a marker to study microglial status and activity, and it remains a focal point for understanding microglial involvement in neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIF-1; Allograft inflammatory factor 1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; DADB-70P7.8; DASS-82G15.2; Em:AF129756.17; Iba; interferon gamma responsive transcript; ionized calcium binding adapter molecule 1; Ionized calcium-binding adapter molecule 1; Microglia response factor; MRF-1; protein BART-1; Protein G1; testis specific
基因别名: AI607846; AIF-1; AIF1; BART-1; Bart1; D17H6S50E; G1; IBA1; IRT-1; IRT1; mrf-1; Mrf1
UniProt ID: (Human) P55008, (Mouse) O70200, (Rat) P55009
Entrez Gene ID: (Human) 199, (Mouse) 11629, (Rat) 29427
microglial cell activation
positive regulation of protein phosphorylation
phagocytosis, engulfment
inflammatory response
negative regulation of gene expression
positive regulation of muscle hyperplasia
Rac protein signal transduction
actin filament polymerization
cellular response to extracellular stimulus
cellular response to hormone stimulus
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
response to axon injury
actin filament bundle assembly
response to glucocorticoid
response to electrical stimulus
cellular response to morphine
cellular response to interferon-gamma
cellular response to hydroperoxide
negative regulation of smooth muscle cell chemotaxis
positive regulation of smooth muscle cell chemotaxis
positive regulation of monocyte chemotaxis
ruffle assembly
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of T cell migration
positive regulation of cell migration
response to cytokine
macrophage activation
