Invitrogen

ID2 Polyclonal Antibody

查看其他15个ID2抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
ID2 Polyclonal Antibody

产品信息

PA5-28939

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

1:100-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Full length human ID2 Recombinant protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.82 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2546415

产品详细信息

Recommended positive controls: HCT116.

Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (82%), Pig (98%), Chicken (94%), Bovine (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297

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基因别名: Ac2-300; AI255428; BHLHB26; C78922; GIG8; Id-2; ID2; ID2A; ID2H; Idb2

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UniProt ID: (Human) Q02363, (Rat) P41137, (Mouse) P41136

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Entrez Gene ID: (Human) 3398, (Rat) 25587, (Mouse) 15902

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功能
protein binding ion channel binding protein dimerization activity protein heterodimerization activity DNA-binding transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter metanephros development natural killer cell differentiation thigmotaxis membranous septum morphogenesis bundle of His development transcription, DNA-templated multicellular organism development adult locomotory behavior positive regulation of gene expression negative regulation of gene expression oligodendrocyte development regulation of lipid metabolic process olfactory bulb development circadian regulation of gene expression mammary gland epithelial cell proliferation regulation of circadian rhythm entrainment of circadian clock by photoperiod enucleate erythrocyte differentiation negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity locomotor rhythm negative regulation of B cell differentiation positive regulation of fat cell differentiation positive regulation of erythrocyte differentiation positive regulation of macrophage differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of blood pressure negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated cell maturation Peyer's patch development embryonic digestive tract morphogenesis positive regulation of smooth muscle cell proliferation neuron fate commitment cell morphogenesis involved in neuron differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation adipose tissue development mammary gland alveolus development epithelial cell differentiation involved in mammary gland alveolus development endodermal digestive tract morphogenesis positive regulation of cell cycle arrest cellular response to lithium ion positive regulation of transcription involved in G1/S transition of mitotic cell cycle cellular senescence regulation of G1/S transition of mitotic cell cycle negative regulation of neural precursor cell proliferation leukocyte differentiation heart development positive regulation of cell proliferation entrainment of circadian clock neuron differentiation positive regulation of cell cycle cell development regulation of transcription, DNA-templated rhythmic process lymph node development
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