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Invitrogen
IFI6 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-50175
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from C-terminal of human IFI6.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total IFI6 protein.
靶标信息
G1P3, also known as Interferon alpha-inducible protein 6 (IFI6) and Interferon-induced protein 6-16, is a 130 amino acid member of the IFI6 family of proteins. Localized to the mitochondria, G1P3 is a multi-pass membrane protein that is induced by IFN-α2β. G1P3 has been shown to play a major role in the apoptosis pathway. Specifically, G1P3 acts as a cell survival protein by inhibiting caspase-3 activity, which antagonizes apoptosis. G1P3 has been implicated in tumorigenesis and is the subject of therapeutic studies, as reducing G1P3-mediated antiapoptotic signals could suggest improved therapies for myeloma or other malignancies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ifi-6-16; Interferon alpha-inducible protein 6; interferon, alpha-inducible protein clone IFI-6-16; Interferon-induced protein 6-16; unnamed protein product; Vbeta 13 S3-EQGLLSTDTQYF-Jbeta 2.3
基因别名: 6-16; FAM14C; G1P3; IFI-6-16; IFI6; IFI616
UniProt ID: (Human) P09912
Entrez Gene ID: (Human) 2537
immune system process
apoptotic process
immune response
regulation of epidermal growth factor receptor signaling pathway
negative regulation of apoptotic process
innate immune response
defense response to virus
negative regulation of mitochondrial depolarization
reactive oxygen species metabolic process
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
cellular response to virus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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