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Immunogen sequence: IKKINPLKEK SIILPKSLIS VVRSATLETK PESKYVSLIT SYQPFSLEKE VVCEEPLSPA TVPGMHTEDN PGKVEHTEEL SSITEVVTTE ENIPDVVPGS HLTPIERESS SPLSSNQSEP GSIALNSYHS RNCSESDHSR NGFDTDSSCL ESHSSLSDSE FPPNNKGEIK TEGQELITVI KAPTSFGYDK PHVLVDLLVD DSGKESLIGY RPTEDSKEFS; Positive Samples: HL-60, THP-1, HeLa, SW620, Mouse lung, Mouse spleen, Mouse heart, Mouse skeletal muscle; Cellular Location: Membrane, Single-pass type I membrane protein
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; immune interferon receptor 1; INF-g receptor; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor 1; interferon-gamma receptor alpha chain
基因别名: CD119; Ifgr; IFN-gammaR; IFNGR; IFNGR1; IMD27A; IMD27B; Nktar
UniProt ID: (Human) P15260, (Mouse) P15261
Entrez Gene ID: (Human) 3459, (Mouse) 15979, (Rat) 116465
分子生物学功能: transmembrane signal receptor