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Abnova
IFT57 Polyclonal Antibody, MaxPab™
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IFT57 Antibody (H00055081-D01P) in WB
Western Blot analysis of IFT57 expression in transfected 293T cell line (H00055081-T02) by IFT57 MaxPab polyclonal antibody.
Lane 1: IFT57 transfected lysate(49.10 KDa).
Lane 2: Non-transfected lysate.
Lane 1: IFT57 transfected lysate(49.10 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00055081-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IFT57 (NP_060480.1, 1 a.a. approximately 429 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MTAALAVVTT SGLEDGVPRS RGEGTGEVVL ERGPGAAYHM FVVMEDLVEK LKLLRYEEEF LRKSNLKAPS RHYFALPTNP GEQFYMFCTL AAWLINKAGR PFEQPQEYDD PNATISNILS ELRSFGRTAD FPPSKLKSGY GEHVCYVLDC FAEEALKYIG FTWKRPIYPV EELEEESVAE DDAELTLNKV DEEFVEEETD NEENFIDLNV LKAQTYHLDM NETAKQEDIL ESTTDAAEWS LEVERVLPQL KVTIRTDNKD WRIHVDQMHQ HRSGIESALK ETKGFLDKLH NEITRTLEKI SSREKYINNQ LENLVQEYRA AQAQLSEAKE RYQQGNGGVT ERTRLLSEVM EELEKVKQEM EEKGSSMTDG APLVKIKQSL TKLKQETVEM DIRIGIVEHT LLQSKLKEKS NMTRNMHATV IPEPATGFY
靶标信息
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dermal papilla-derived protein 8; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; huntingtin-interacting protein-1 protein interactor; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; Vestrogen-related receptor beta like 1
基因别名: 4833420A15Rik; DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2
UniProt ID: (Human) Q9NWB7, (Mouse) Q8BXG3
Entrez Gene ID: (Human) 55081, (Mouse) 73916
neural tube closure
heart looping
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
smoothened signaling pathway
intraciliary transport
cilium assembly
regulation of apoptotic process
negative regulation of epithelial cell proliferation
left/right pattern formation
cilium morphogenesis
