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产品信息
MA5-32485
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JJ092-3
抗原
Recombinant protein within Human IGF2 aa 25-121
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809762
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
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生物信息学
蛋白别名: FLJ22066; FLJ44734; H-IGF-2; IGF; IGF-II; Insulin like growth factor; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor type 2; preptin; Somatomedin-A; T3M-11-derived growth factor
基因别名: C11orf43; GRDF; IGF-II; IGF2; PP1446; PP9974
UniProt ID: (Human) P01344
Entrez Gene ID: (Human) 3481
skeletal system development
ossification
positive regulation of protein phosphorylation
platelet degranulation
glucose metabolic process
regulation of gene expression by genetic imprinting
regulation of transcription, DNA-templated
multicellular organism development
female pregnancy
memory
positive regulation of cell proliferation
insulin receptor signaling pathway
response to radiation
response to nutrient levels
response to estradiol
response to nicotine
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
wound healing
positive regulation of activated T cell proliferation
response to drug
positive regulation of catalytic activity
positive regulation of MAPK cascade
cellular protein metabolic process
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of mitotic nuclear division
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of insulin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
positive regulation of protein kinase B signaling
cellular response to mechanical stimulus
positive regulation of protein serine/threonine kinase activity
positive regulation of receptor activity
positive regulation of glycogen (starch) synthase activity
