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This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
MA5-15400 targets IGFBP2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15400 immunogen is purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
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IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IBP-2; IGF binding protein 2; IGF-binding protein 2; IGFBP; Insulin like growth factor binding protein; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2; OTTHUMP00000207753
基因别名: BP2; IBP2; IGF-BP53; IGFBP2
UniProt ID: (Human) P18065
Entrez Gene ID: (Human) 3485
分子生物学功能: protease inhibitor