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Invitrogen
IGFBP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79451
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human IGFBP-3 (214-252aa RREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCR).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat heart tissue, rat brain tissue, rat liver tissue, rat PC-12 whole cellhuman U-87MG whole cellmouse kidney tissue, mouse heart tissue, mouse brain tissue. IHC: Human Intestinal Cancer tissue.
靶标信息
IGFBP3 is a gene that belongs to the insulin-like growth factor binding protein (IGFBP) family. The gene encodes a protein that contains both an IGFBP domain and a thyroglobulin type-I domain. This protein is known to form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. The complex circulates in the plasma and prolongs the half-life of IGFs while also altering their interaction with cell surface receptors. Various isoforms of the gene have been identified through alternate transcriptional splice variants. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BP53; Growth hormone dependent binding protein; IBP-3; IGF binding protein 3; IGF-binding protein 3; IGFBP; IGFBP-3; Insulin like growth factor binding protein; Insulin-like growth factor binding protein 3 precursor; insulin-like growth factor-binding protein (IGF-BP3); Insulin-like growth factor-binding protein 3; tcag7.703
基因别名: AI649005; IBP3; IGF-BP3; IGFBP-3; IGFBP3; IGgfbp3
UniProt ID: (Mouse) P47878, (Rat) P15473
Entrez Gene ID: (Mouse) 16009, (Rat) 24484
regulation of cell growth
negative regulation of protein phosphorylation
protein phosphorylation
negative regulation of cell proliferation
regulation of glucose metabolic process
negative regulation of smooth muscle cell migration
regulation of growth
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
positive regulation of insulin-like growth factor receptor signaling pathway
type B pancreatic cell proliferation
positive regulation of myoblast differentiation
negative regulation of smooth muscle cell proliferation
osteoblast differentiation
regulation of insulin-like growth factor receptor signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
