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Invitrogen
IGFL2 Polyclonal Antibody
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IGFL2 Antibody (PA5-99820) in ICC/IF
Immunofluorescent analysis of IGFL2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and IGFL2 polyclonal antibody (Product # PA5-99820) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-99820
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IGFL2(Accession Q6UWQ7), corresponding to amino acid residues L18-P68.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total IGFL2.
靶标信息
The insulin gene family, comprised of insulin, relaxin and insulin-like growth factors I and II (IGF-I and IGF-II), represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somato-medins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I and -II are critical regulators of cell proliferation and differentiation. Most of the growth promoting properties of both ligands are mediated by the IGF-I receptor (IGF-IR). IGF- I and -II, respectively known as somatomedin C and somatomedin A, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II is induced by placental lactogen during prenatal development. IGF-II is a fetal growth factor, influenced by placental lactogen and abundantly expressed by placental trophoblasts. IGF-II and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. The human IGF-II gene maps to chromosome 11p15.5, encoding a 180 amino acid protein which is the precursor to IGF-II.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IGF; IGF-like family member 2; Insulin growth factor-like family member 2; Insulin like growth factor
基因别名: IGFL2; UNQ645; UNQ645/PRO1275; VPRI645
UniProt ID: (Human) Q6UWQ7
Entrez Gene ID: (Human) 147920
