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Invitrogen
IGHMBP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103794
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IGHMBP2(Accession P38935), corresponding to amino acid residues E483-R533.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IGHMBP2.
Target Information
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AEP; antifreeze enhancer-binding protein; Antifreeze enhancer-binding protein ortholog; ATP-dependent helicase IGHMBP2; cardiac transcription factor 1; DNA-binding protein SMUBP-2; GF-1; Glial factor 1; immunoglobulin mu binding protein 2; Immunoglobulin mu-binding protein 2; immunoglobulin S mu binding protein 2; neuromuscular degeneration; p110 subunit; unnamed protein product; zinc finger, AN1-type domain 7
Gene Aliases: AEP; CATF1; CMT2S; HCSA; HMN6; HMNR1; IGHMBP2; nmd; RIPE3b1; sma; SMARD1; Smbp-2; SMBP2; SMUBP2; ZFAND7
UniProt ID: (Rat) Q9EQN5
Entrez Gene ID: (Human) 3508, (Mouse) 20589, (Rat) 29532
tRNA binding
nucleic acid binding
DNA binding
DNA helicase activity
single-stranded DNA binding
RNA binding
single-stranded RNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
RNA-dependent ATPase activity
zinc ion binding
ATPase activity
5'-3' RNA helicase activity
double-stranded DNA-dependent ATP-dependent DNA helicase activity
identical protein binding
ribosome binding
5'-3' DNA helicase activity
general transcription initiation factor binding
nucleotide binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor binding
hydrolase activity
ATP-dependent 5'-3' RNA helicase activity
ATP-dependent 5'-3' DNA helicase activity
metal ion binding
protein self-association
DNA metabolism protein
cellular response to DNA damage stimulus
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
translation
spinal cord motor neuron differentiation
DNA duplex unwinding
protein homooligomerization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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