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Abnova
IGSF6 Monoclonal Antibody (1A10)
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产品信息
H00010261-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1A10
抗原
IGSF6 (AAH17844.1, 29 a.a. approximately 241 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: TLSVTQPWYL EVDYTHEAVT IKCTFSATGC PSEQPTCLWF RYGAHRPENL CLDGCKSEAD KFTVREALKE NQVSLTVNRV TSNDSAIYIC GIAFPSVPEA RAKQTGGGTT LVVREIKLLS KELRNFLTAL VSLLSVYVTG VCVAFILLSK SKSNPLRNKK IKEDSQKKKS ARRIFQEIAQ ELYHKRHVET NQQSEKDNNT YENRRVLSNY ERP
靶标信息
IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene. The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: down-regulated by activation (immunoglobulin superfamily); IgSF6; Immunoglobulin superfamily member 6; immunoglobulin superfamily, member 6; Protein DORA
基因别名: DORA; IGSF6
UniProt ID: (Human) O95976
Entrez Gene ID: (Human) 10261
