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Abnova
IKIP Monoclonal Antibody (2D5)
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产品信息
H00121457-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D5
抗原
IKIP (NP_710154.1, 1 a.a. approximately 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL SLGTCLGLAW FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKL ESTESILQEA TSSMSLMTQF EQEVSNLQDI MHDIQNNEEV LTQRMQSLNE KFQNITDFWK RSLEEMNINT DIFKSEAKHI HSQVTVQINS AEQEIKLLTE RLKDLEDSTL RNIRTVKRQE EEDLLRVEEQ LGSDTKAIEK LEEEQHALFA RDEDLTNKLS DYEPKVEECK THLPTIESAI HSVLRVSQDL IETEKKMEDL TMQMFNMEDD MLKAVSEIME MQKTLEGIQY DNSILKMQNE LDILKEKVHD FIAYSSTGEK GTLKEYNIEN KGIGGDF
靶标信息
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: I kappa B kinase interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK interacting protein; IKK-interacting protein; Inhibitor of nuclear factor kappa-B kinase-interacting protein
基因别名: IKBIP; IKIP
UniProt ID: (Human) Q70UQ0
Entrez Gene ID: (Human) 121457
