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Invitrogen
IKK alpha/beta Recombinant Rabbit Monoclonal Antibody (K01_3K24)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA564341
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_3K24
抗原
Recombinant protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B-kinase beta; IkappaB kinase; IkappaB kinase alpha; IKK alpha; IKK-1; IKK-2; IKK-A; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB; TCF-16; TCF17; Transcription factor 16
基因别名: AI132552; AI256658; AIM-1; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKBKB; IKK-2; IKK-beta; IKK1; IKK2; IKK[b]; IKKA; IKKB; IKKbeta; NFKBIKA; TCF16
UniProt ID: (Mouse) O88351, (Rat) Q9QY78
Entrez Gene ID: (Mouse) 12675, (Rat) 309361, (Mouse) 16150, (Rat) 84351
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
protein kinase binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
morphogenesis of an epithelial sheet
protein phosphorylation
I-kappaB phosphorylation
Rho protein signal transduction
lactation
response to organic substance
phosphorylation
signal transduction by protein phosphorylation
osteoclast differentiation
response to lipopolysaccharide
mammary gland epithelial cell proliferation
response to muscle stretch
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
striated muscle cell differentiation
mammary gland alveolus development
cellular response to tumor necrosis factor
skeletal muscle contraction
response to toxic substance
response to acetate
response to hydroperoxide
response to drug
response to amino acid
B cell homeostasis
positive regulation of cell proliferation
positive regulation of sodium ion transport
neuron projection development
serine phosphorylation of STAT protein
positive regulation of NF-kappaB transcription factor activity
positive regulation of neuron death
positive regulation of cation channel activity
response to fatty acid
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