Invitrogen

IKK alpha/beta Recombinant Rabbit Monoclonal Antibody (SN63-02)

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说明书
实验方案
问题与答案
技术支持
IKK alpha/beta Recombinant Rabbit Monoclonal Antibody (SN63-02)

产品信息

MA5-32274

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SN63-02

抗原

Recombinant protein within Human IKK beta aa 450-652
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2809560

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKK alpha; IKK-1; IKK-2; IKK-A; IKK-a kinase; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor NFkappaB inhibitor kinase alpha; Serine/threonine protein kinase IKBKB; TCF-16; TCF17; Transcription factor 16

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基因别名: AI132552; AI256658; AIM-1; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKBKB; IKK-2; IKK-alpha; IKK-beta; IKK1; IKK2; IKK[b]; IKKA; IKKB; IKKbeta; IMD15; NFKBIKA; NFKBIKB; TCF16

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UniProt ID: (Human) O15111, (Human) O14920, (Mouse) O88351, (Rat) Q9QY78

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Entrez Gene ID: (Human) 1147, (Mouse) 12675, (Rat) 309361, (Human) 3551, (Mouse) 16150, (Rat) 84351

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功能
protein kinase activity protein binding ATP binding IkappaB kinase activity protein homodimerization activity protein heterodimerization activity scaffold protein binding nucleotide binding protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding non-receptor serine/threonine protein kinase protein modifying enzyme
参与通路
stimulatory C-type lectin receptor signaling pathway skeletal muscle contraction protein phosphorylation inflammatory response immune response I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation Rho protein signal transduction response to virus response to toxic substance anatomical structure morphogenesis response to acetate regulation of tumor necrosis factor-mediated signaling pathway response to lipopolysaccharide response to hydroperoxide TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway response to drug positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid innate immune response positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity striated muscle cell differentiation stress-activated MAPK cascade nucleotide-binding oligomerization domain containing signaling pathway cellular response to tumor necrosis factor morphogenesis of an epithelial sheet lactation response to organic substance phosphorylation signal transduction by protein phosphorylation osteoclast differentiation mammary gland epithelial cell proliferation response to muscle stretch odontogenesis of dentin-containing tooth mammary gland alveolus development positive regulation of cell proliferation positive regulation of neuron projection development cortical actin cytoskeleton organization neuron projection development tumor necrosis factor-mediated signaling pathway negative regulation of myosin-light-chain-phosphatase activity regulation of phosphorylation serine phosphorylation of STAT protein negative regulation of apoptotic process positive regulation of transcription, DNA-templated interleukin-1-mediated signaling pathway response to fatty acid establishment of protein localization to plasma membrane positive regulation of neuron death regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly B cell homeostasis positive regulation of sodium ion transport positive regulation of cation channel activity
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