Invitrogen

IKK beta Monoclonal Antibody (10AG2)

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说明书
实验方案
问题与答案
技术支持
IKK beta Monoclonal Antibody (10AG2)

产品信息

MA5-16154

应用
建议稀释比
已发表文章

免疫印迹 (WB)

2-4 µg/mL
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免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:10-1:500
-

免疫细胞化学 (ICC/IF)

2-5 µg/mL
-

流式细胞分析 (Flow)

0.25-0.5 µg/10^6 cells
-

免疫沉淀 (IP)

1:10-1:500
-

亲和纯化 (AP)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

10AG2

抗原

Full-length recombinant human IKK beta protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2537673

产品详细信息

Suggested positive control: Daudi, HeLa, NIH-3T3.

靶标信息

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB

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基因别名: AI132552; AIM-1; IKBKB; IKK-2; IKK-beta; IKK2; IKK[b]; IKKB; IKKbeta; IMD15; NFKBIKB

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UniProt ID: (Human) O14920, (Mouse) O88351, (Rat) Q9QY78

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Entrez Gene ID: (Human) 3551, (Mouse) 16150, (Rat) 84351

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功能
protein kinase activity protein serine/threonine kinase activity protein binding ATP binding IkappaB kinase activity protein kinase binding protein homodimerization activity protein heterodimerization activity scaffold protein binding nucleotide binding receptor signaling protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase protein modifying enzyme
参与通路
stimulatory C-type lectin receptor signaling pathway skeletal muscle contraction protein phosphorylation inflammatory response I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation positive regulation of cell proliferation response to virus response to toxic substance regulation of tumor necrosis factor-mediated signaling pathway positive regulation of neuron projection development cortical actin cytoskeleton organization neuron projection development response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway negative regulation of myosin-light-chain-phosphatase activity TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway regulation of phosphorylation response to drug serine phosphorylation of STAT protein negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade nucleotide-binding oligomerization domain containing signaling pathway interleukin-1-mediated signaling pathway response to fatty acid cellular response to tumor necrosis factor establishment of protein localization to plasma membrane positive regulation of neuron death regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly B cell homeostasis positive regulation of sodium ion transport phosphorylation signal transduction by protein phosphorylation positive regulation of cation channel activity
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