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Invitrogen
IKK epsilon Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102307
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IKBKE(Accession Q14164), corresponding to amino acid residues L681-V716.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total IKK epsilon.
靶标信息
IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKe; IKK-related kinase; Inducible I kappa-B kinase; inducible IKappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1
基因别名: AW558201; IKBKE; IKK-E; IKK-i; IKKE; IKKepsilon; IKKI; KIAA0151
UniProt ID: (Mouse) Q9R0T8
Entrez Gene ID: (Human) 9641, (Rat) 363984, (Mouse) 56489
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
protein phosphatase binding
ubiquitin protein ligase binding
K48-linked polyubiquitin binding
identical protein binding
K63-linked polyubiquitin binding
NF-kappaB-inducing kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
activation of innate immune response
response to stress
immune response
intrinsic apoptotic signaling pathway in response to DNA damage
gene expression
positive regulation of lipid storage
positive regulation of type I interferon production
response to cytokine
response to type I interferon
response to interferon-beta
intracellular signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
mRNA stabilization
defense response to virus
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
interleukin-17-mediated signaling pathway
cellular response to virus
protein phosphorylation
I-kappaB phosphorylation
NIK/NF-kappaB signaling
cellular response to DNA damage stimulus
phosphorylation
signal transduction by protein phosphorylation
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