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Invitrogen
IL-1 alpha (Bermekimab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody
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IL-1 alpha (Bermekimab Biosimilar) Antibody (MA5-42060) in ELISA
ELISA binding of IL-1 alpha (Bermekimab Biosimilar) to immobilized recombinant antigen (coated at 5 µg/mL). IL-1 alpha (Bermekimab Biosimilar) monoclonal antibody (Product # MA5-42060) was serially diluted from 10,000 ng/mL to 0.64 ng/mL.
产品信息
MA5-42060
产品规格
种属反应
Human
宿主/亚型
Artificial Control
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human IL1A
偶联物
形式
Liquid
浓度
2.34 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.5
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTLA8; Hematopoietin-1; IL 1 a; IL 1α; IL-1 alpha; IL17; IL1A; IL1α; ILN; Interleukin; interleukin 17; Interleukin-1 alpha; Interleukin-17A; Interleukin1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha; RP23-160G19.8; unnamed protein product
基因别名: IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1
UniProt ID: (Human) P01583
Entrez Gene ID: (Human) 3552
fever generation
positive regulation of cytokine production
connective tissue replacement involved in inflammatory response wound healing
cellular sodium ion homeostasis
apoptotic process
response to stress
inflammatory response
immune response
negative regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of immature T cell proliferation in thymus
cellular response to heat
ectopic germ cell programmed cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
response to copper ion
positive regulation of protein secretion
positive regulation of cell division
regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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