Invitrogen

IL-10 Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持
IL-10 Polyclonal Antibody

产品信息

PA5-85660

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:10,000
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
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免疫组化（冰冻） (IHC (F))

1:100-1:1,000
-

酶联免疫吸附实验 (ELISA)

1:-1:10,000
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产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human IL10. The exact sequence is proprietary.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.17 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792799

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Rhesus Monkey (100%), Chimpanzee (100%).

Positive Control: 293T, human IL10-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CSIF; Cytokine synthesis inhibitory factor; H-IL-10; il 10; IL-10; ILN; Interleukin; Interleukin-10; Interleukin10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor

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基因别名: CSIF; GVHDS; IL-10; IL10; IL10A; TGIF

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UniProt ID: (Human) P22301, (Mouse) P18893

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Entrez Gene ID: (Human) 3586, (Mouse) 16153

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功能
cytokine activity interleukin-10 receptor binding protein binding growth factor activity
参与通路
negative regulation of cytokine production response to molecule of bacterial origin negative regulation of cytokine secretion involved in immune response negative regulation of chronic inflammatory response to antigenic stimulus positive regulation of B cell apoptotic process inflammatory response immune response regulation of gene expression negative regulation of myeloid dendritic cell activation negative regulation of B cell proliferation negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production receptor biosynthetic process negative regulation of tumor necrosis factor biosynthetic process defense response to bacterium defense response to protozoan negative regulation of apoptotic process negative regulation of growth of symbiont in host negative regulation of nitric oxide biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade positive regulation of cytokine secretion negative regulation of inflammatory response negative regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid regulation of sensory perception of pain negative regulation of cytokine activity branching involved in labyrinthine layer morphogenesis cellular response to lipopolysaccharide cytoplasmic sequestering of NF-kappaB cell-cell signaling aging response to activity response to inactivity hemopoiesis B cell differentiation leukocyte chemotaxis negative regulation of interleukin-1 production negative regulation of interleukin-18 production negative regulation of interleukin-8 production response to insulin response to carbon monoxide cellular response to hepatocyte growth factor stimulus type 2 immune response B cell proliferation negative regulation of T cell proliferation response to drug regulation of isotype switching negative regulation of MHC class II biosynthetic process negative regulation of interferon-alpha biosynthetic process cellular response to estradiol stimulus negative regulation of chemokine (C-C motif) ligand 5 production regulation of complement-dependent cytotoxicity negative regulation of endothelial cell apoptotic process
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