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Invitrogen
IL-13 Recombinant Rabbit Monoclonal Antibody (21H6H5)
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产品信息
701123
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
21H6H5
抗原
Recombinant protein corresponding to amino acids 22-131 of human IL-13
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with equine, human, non-human primate and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALRH; ALRH antibody; BHR1; il 13; IL-13; ILN; Interleukin; Interleukin-13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30 antibody; P600 antibody; T-cell activation protein P600
基因别名: IL-13; IL13; NC30; P600
UniProt ID: (Human) P35225, (Mouse) P20109
Entrez Gene ID: (Human) 3596, (Mouse) 16163
microglial cell activation
positive regulation of immunoglobulin production
inflammatory response
immune response
regulation of proton transport
positive regulation of B cell proliferation
positive regulation of connective tissue growth factor production
negative regulation of NAD(P)H oxidase activity
response to nicotine
positive regulation of tyrosine phosphorylation of Stat6 protein
positive regulation of macrophage activation
positive regulation of ion transport
positive regulation of mast cell degranulation
positive regulation of smooth muscle cell proliferation
positive regulation of protein secretion
positive regulation of release of sequestered calcium ion into cytosol
cellular response to cytokine stimulus
negative regulation of transforming growth factor beta production
negative regulation of neuron death
negative regulation of complement-dependent cytotoxicity
positive regulation of pancreatic stellate cell proliferation
negative regulation of endothelial cell apoptotic process
movement of cell or subcellular component
signal transduction
cell-cell signaling
response to lipopolysaccharide
response to ethanol
cellular response to mechanical stimulus
negative regulation of lung ciliated cell differentiation
positive regulation of lung goblet cell differentiation
