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Invitrogen
IL-18 Monoclonal Antibody (7G8), eBioscience™
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IL-18 Antibody (BMS1042) in WB
Toxins 2023 -
Deoxynivalenol (DON) treatment affected the protein expression levels of TXNIP, inflammasomes, and pro-inflammatory cytokine. ( A ) Protein expression level of TXNIP was evaluated by Western blotting assay. ( B ) Protein expression levels of inflammasomes (NLRP3, ASC, and CASP1) were evaluated using Western blotting assay. ( C ) Protein expression level of IL-18 was evaluated by Western blotting assay. The ... View More
产品信息
BMS1042
产品规格
种属反应
Pig
已发表种属
Pig
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7G8
抗原
Rec. Pig IL-18
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2-7.4
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: BMS1042 (7G8) recognises natural and recombinant porcine IL-18. The antibody does not recognise porcine IL-1beta, IL-8, IL-12 or IFN-gamma, nor does it cross react with human or murine IL-18.
Applications Tested: ELISA, Western Blotting.
靶标信息
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cytokine; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; ILN; Interferon gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
基因别名: IGIF; IL-18; IL18
UniProt ID: (Pig) O19073
Entrez Gene ID: (Pig) 397057
MAPK cascade
angiogenesis
inflammatory response
cell proliferation
positive regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of macrophage derived foam cell differentiation
positive regulation of phosphatidylinositol 3-kinase signaling
natural killer cell activation
lipopolysaccharide-mediated signaling pathway
activation of protein kinase B activity
interferon-gamma production
interleukin-6 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
interleukin-18-mediated signaling pathway
T-helper 1 cell cytokine production
positive regulation of activated T cell proliferation
neutrophil activation
natural killer cell mediated cytotoxicity
positive regulation of tyrosine phosphorylation of STAT protein
cholesterol homeostasis
positive regulation of T-helper 2 cell differentiation
negative regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of NF-kappaB transcription factor activity
positive regulation of NK T cell proliferation
positive regulation of protein kinase B signaling
triglyceride homeostasis
cellular response to organic cyclic compound
positive regulation of cold-induced thermogenesis
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
