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Invitrogen
IL-19 Polyclonal Antibody, PeproTech®
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IL-19 Antibody (500-P189-1MG) in WB
Western Blot: To detect Human IL-19 by Western Blot analysis IL-19 Polyclonal Antibody (Product # 500-P189-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human IL-19 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P189-1MG
产品规格
种属反应
Human
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived Recombinant Human IL-19
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
AA Sequence of recombinant protein: MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-19. Anti-Human IL-19-specific antibody was purified by affinity chromatography employing an immobilized Human IL-19 matrix.
Sandwich ELISA: To detect Human IL-19 by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human IL-19 (500-P189Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human IL-19.
Western Blot: To detect Human IL-19 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human IL-19 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: il 19; IL-19; ILN; Interleukin; Interleukin-19; Interleukin19; MDA-1; melanoma differentiation associated protein-like protein; Melanoma differentiation-associated protein-like protein; NG.1
基因别名: IL-10C; IL19; MDA1; NG.1; ZMDA1
UniProt ID: (Human) Q9UHD0
Entrez Gene ID: (Human) 29949
apoptotic process
inflammatory response
immune response
signal transduction
interleukin-6 biosynthetic process
positive regulation of JAK-STAT cascade
reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
