Invitrogen

IL-4 Polyclonal Antibody

12个已发表图片
16 篇参考文献
查看其他90个IL-4抗体

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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
IL-4 Polyclonal Antibody

产品信息

PA5-25165

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

-
查看12篇已发表文章 12篇已发表文章

免疫组化（石蜡） (IHC (P))

1:10-1:50
查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

1:10-1:50
-
产品规格

种属反应

Human, Mouse

已发表种属

C. elegans, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human L4
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2542665

产品详细信息

This antibody is predicted to react with non-human primate based on sequence homology.

靶标信息

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: B cell growth factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; B_cell stimulatory factor 1; Binetrakin; BSF-1; H-IL-4; IGG1 induction factor; IL-4; ILN; Interleukin; interleukin 4 variant 2; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402; Pitrakinra

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基因别名: BCGF-1; BCGF1; BSF-1; BSF1; IL-4; IL4

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UniProt ID: (Human) P05112, (Mouse) P07750

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Entrez Gene ID: (Human) 3565, (Mouse) 16189

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功能
cytokine activity interleukin-4 receptor binding protein binding growth factor activity cytokine receptor binding interleukin superfamily
参与通路
microglial cell activation innate immune response in mucosa positive regulation of defense response to virus by host T-helper 1 cell lineage commitment negative regulation of acute inflammatory response negative regulation of chronic inflammatory response chemotaxis immune response cellular defense response female pregnancy response to nutrient cholesterol metabolic process regulation of proton transport negative regulation of epithelial cell migration response to organic cyclic compound B cell differentiation positive regulation of B cell proliferation B cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-13 production response to cytokine T-helper 2 cell cytokine production type 2 immune response positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of phosphorylation response to drug positive regulation of tyrosine phosphorylation of Stat5 protein defense response to protozoan myeloid dendritic cell differentiation negative regulation of macrophage activation negative regulation of apoptotic process positive regulation of mast cell degranulation negative regulation of nitric oxide biosynthetic process T-helper 2 cell differentiation positive regulation of chemokine biosynthetic process connective tissue growth factor biosynthetic process regulation of isotype switching positive regulation of MHC class II biosynthetic process response to ethanol positive regulation of T cell differentiation negative regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of sequence-specific DNA binding transcription factor activity retina development in camera-type eye negative regulation of white fat cell proliferation cellular response to mercury ion positive regulation of mononuclear cell migration dendritic cell differentiation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of myoblast fusion negative regulation of complement-dependent cytotoxicity negative regulation of T-helper 17 cell differentiation negative regulation of endothelial cell apoptotic process positive regulation of eosinophil chemotaxis negative regulation of extrinsic apoptotic signaling pathway positive regulation of protein phosphorylation positive regulation of immunoglobulin production positive regulation of cell proliferation B cell activation regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of T cell activation positive regulation of B cell activation
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