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Invitrogen
IL-5 Recombinant Rabbit Monoclonal Antibody (R013)
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IL-5 Antibody (MA5-29367) in Neu
Cell Proliferation Induced by IL-5 and Neutralization by IL-5 Recombinant Rabbit Monoclonal Antibody (R013) (Product # MA5-29367). Human IL-5 stimulates proliferation in the TF-1 human erythroleukemic cell line. Proliferation elicited by Recombinant Human IL-5 (1.25 ng/mL) is neutralized by increasing concentrations of IL-5 Recombinant Rabbit Monoclonal Antibody (R013). The ND50is typically 2-8 ng/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-29367
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
R013
抗原
Recombinant Human IL-5/IL5/Interleukin 5 protein (Ile20-Ser134)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.67 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
Histidine/arginine, pH 6, with 120mM NaCl, 0.02% Tween 80
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human IL-5/IL5/Interleukin 5.
靶标信息
IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell differentiation factor I; Eosinophil differentiation factor; IL-5; ILN; Interleukin; Interleukin-5; Interleukin5; T-cell replacing factor; TRF
基因别名: IL5
Entrez Gene ID: (Human) 3567
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