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Invitrogen
IL-5 Monoclonal Antibody (TRFK5), Biotin
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产品信息
MM550CB
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Hamster,
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
TRFK5
抗原
Recombinant mouse IL-5
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 4% BSA
内含物
proprietary Preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MM550CB targets IL-5 in ELISA, and WB applications and shows reactivity with mouse samples.
The MM550CB immunogen is recombinant mouse IL-5.
MM550CB detects IL-5 which has a predicted molecular weight of approximately 13 kDa.
The MM550CB mouse IL5 antibody (biotinylated conjugate of clone TRFK5) has successfully been paired as the detection antibody in a sandwich ELISA with capture antibody MM550D (clone TRFK4). Typical dilutions for sandwich ELISA include 1 µg/mL for coating and 0.125 - 0.25 µg/mL for detection.
Biotinylated antibody MM550CB (clone TRFK5) and antibody MM550D (clone TRFK4) have successfully been used in combination with recombinant mouse IL5 protein SMIL5 in ELISA applications.
This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified.
靶标信息
IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell growth factor II; BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; IL-5; ILN; Interleukin; Interleukin-5; Interleukin5; T-cell replacing factor; TRF
基因别名: Il-5; Il5
UniProt ID: (Mouse) P04401
Entrez Gene ID: (Mouse) 16191
immune response
positive regulation of cell proliferation
cytokine-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of eosinophil differentiation
positive regulation of transcription, DNA-templated
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of podosome assembly
