Invitrogen

IL-8 (CXCL8) Monoclonal Antibody (8M6)

Name: IL-8 (CXCL8) Monoclonal Antibody (8M6)
Brand: Invitrogen
SKU: MA1-82421

查看其他62个IL-8抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA1-82421

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

流式细胞分析 (Flow)

1:10

酶联免疫吸附实验 (ELISA)

5 µg/mL

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Bovine, Dog, Ferret, Mustelid, Mink, Sheep, Pig, Rabbit

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

8M6

抗原

Recombinant ovine IL-8

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

purified

保存液

PBS

内含物

<0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2126346

产品详细信息

This antibody has also been reported to neutralize the bioactivity of ovine IL-8, however prior removal of sodium azide may be necessary for functional assays. Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti Ovine Interleukin-8 antibody, clone 8M6 recognizes ovine interleukin-8 (IL-8), also known as C-X-C motif chemokine 8.

靶标信息

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; AMCF-I; ANX7; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; cytokine 8; IL-8; ILN; Interleukin; Interleukin-8; Interleukin8; NAP-1; neutrophil activating peptide 1; neutrophil and T-lymphocyte chemotactic and activating factor; Neutrophil attractant/activation protein 1; neutrophil attractant/activation protein-1; Permeability factor 1; PF1; RP11-537A6.8; RPF1; SNX; SYNEXIN

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基因别名: AMCF-I; CXCL8; IL-8; IL8