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Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cytokine-like protein Mob-5; IL 24; IL-24; Interleukin; Interleukin-24
基因别名: Il24; Mda-7; Mda7; Mob5
UniProt ID: (Rat) Q9JI24
Entrez Gene ID: (Rat) 170819