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Invitrogen
IL2RG Monoclonal Antibody (TUGh4)
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FIGURE: 1 / 2
IL2RG Antibody (MA562191) in Flow
Flow cytometry (surface staining) of IL2RG in human peripheral whole blood. Samples were incubated with IL2RG monoclonal antibody (Product # MA562191) using a dilution of 4 µg/mL. Separation of human lymphocytes (red-filled) from human CD132 negative blood debris (black-dashed).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA562191
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Rat
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
TUGh4
Immunogen
Human CD132-transfected cell line.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD132 antigen; common cytokine receptor gamma chain; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2R gamma; interleukin 2 receptor gamma chain; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); nonfunctional common cytokine receptor gamma chain; p64; unnamed protein product
Gene Aliases: CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785, (Dog) P40321
Entrez Gene ID: (Human) 3561, (Dog) 403851
leukocyte homeostasis
immune response
signal transduction
JAK-STAT cascade
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
cellular homeostasis
lymphocyte differentiation
natural killer cell activation
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of T cell differentiation
positive regulation of phagocytosis
positive regulation of leukocyte proliferation
negative regulation of Fas signaling pathway
positive regulation of leukocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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