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In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-1 RII, rhIL-2 R beta, rhIL-2 R gamma, rhIL-3 R is observed and less than 1% cross-reactivity with rhIL-1 RI, rhIL-4 R, rhIL-6 R, rhIL-7 R, rhIL-9 R, and rhIL-10 R is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD125; CD125 antigen; CDw125; IL-5 receptor subunit alpha; IL-5R subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; Interleukin-5 receptor subunit alpha
基因别名: CD125; CDw125; HSIL5R3; IL5R; IL5RA
UniProt ID: (Human) Q01344
Entrez Gene ID: (Human) 3568
分子生物学功能: transmembrane signal receptor