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Invitrogen
IL5RA Polyclonal Antibody
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IL5RA Antibody (PA5-95025) in WB
Western blot analysis of IL5RA in Lane 1: A549 whole cell lysate (40 µg), Lane 2: SMMC whole cell lysate (40 µg), Lane 3: U87 whole cell lysate (40 µg), Lane 4: 293T whole cell lysate (40 µg), Lane 5: PANC whole cell lysate (40 µg), Lane 6: HeLa whole cell lysate (40 µg), Lane 7: Jurkat whole cell lysate (40 µg), Lane 8: RAJI whole cell lysate (40 µg), Lane 9: CEM whole cell lysate (40 µg). Samples were incubated with IL5RA polyclonal antibody (Product # PA5-95025).
产品信息
PA5-95025
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human IL5RA (53-68aa NPDQEQRNVNLEYQVK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: A549 whole cell, SMMC whole cell, U87 whole cell, 293T whole cell, PANC whole cell, HELA whole cell, JURKAT whole cell, RAJI whole cell, CEM whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD125; CD125 antigen; CDw125; IL-5 receptor subunit alpha; IL-5R subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; Interleukin-5 receptor subunit alpha
基因别名: CD125; CDw125; HSIL5R3; IL5R; IL5RA
UniProt ID: (Human) Q14633
Entrez Gene ID: (Human) 3568
