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Invitrogen
INSM1 Monoclonal Antibody (CL11630)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-44174
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL11630
抗原
Recombinant protein corresponding to Human INSM1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.0 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.
靶标信息
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IA-1; insulinoma-associated 1; zinc finger protein IA-1
基因别名: IA-1; IA1
UniProt ID: (Human) Q01101
Entrez Gene ID: (Human) 3642
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
cyclin binding
chromatin DNA binding
histone deacetylase binding
binding, bridging
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
type B pancreatic cell differentiation
pancreatic A cell differentiation
noradrenergic neuron development
negative regulation of cell proliferation
regulation of gene expression
regulation of cell cycle process
cell differentiation
neuron differentiation
regulation of cell proliferation
norepinephrine biosynthetic process
regulation of protein complex assembly
positive regulation of cell differentiation
regulation of cell cycle
transdifferentiation
adrenal chromaffin cell differentiation
sympathetic ganglion development
positive regulation of neural precursor cell proliferation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
