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Fabgennix
IP3 receptor Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ITPR1-101AP
产品规格
种属反应
Bovine,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1,4,5-triphosphate receptor type 2 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
基因别名: D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; Ip3r; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1
UniProt ID: (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Bovine) 317697, (Mouse) 16438, (Rat) 25262
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium-release channel activity
phosphatidylinositol binding
inositol 1,4,5 trisphosphate binding
ion channel activity
calcium channel activity
protein binding
protein C-terminus binding
calcium channel inhibitor activity
protein phosphatase binding
protein complex binding
ligand-gated ion channel
inositol phosphate-mediated signaling
release of sequestered calcium ion into cytosol
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
response to hypoxia
transport
ion transport
calcium ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
post-embryonic development
endoplasmic reticulum calcium ion homeostasis
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
positive regulation of calcium ion transport
transmembrane transport
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
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