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IRAK-M Polyclonal Antibody

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IRAK-M Polyclonal Antibody

产品信息

600-401-954

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:300-1:1,000
-

免疫细胞化学 (ICC/IF)

10 µg/mL
-

酶联免疫吸附实验 (ELISA)

1:5,000-1:20,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

IRAK-M Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids from the c-terminus of human IRAK-M.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ13601; IL-1 receptor-associated kinase M; Inactive IL-1 receptor-associated kinase 3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IRAK-M; irak3

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基因别名: 4833428C18Rik; AI563835; IRAK-M; IRAK3

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UniProt ID: (Mouse) Q8K4B2

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Entrez Gene ID: (Mouse) 73914, (Rat) 314870

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功能
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein homodimerization activity protein heterodimerization activity molecular_function
参与通路
negative regulation of cytokine-mediated signaling pathway toll-like receptor signaling pathway protein phosphorylation apoptotic process signal transduction response to virus positive regulation of macrophage tolerance induction negative regulation of macrophage cytokine production phosphorylation cytokine-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to lipopolysaccharide negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway intracellular signal transduction negative regulation of protein catabolic process regulation of apoptotic process negative regulation of protein complex disassembly regulation of protein complex disassembly response to exogenous dsRNA negative regulation of MAP kinase activity negative regulation of innate immune response protein autophosphorylation positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 biological_process
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性能保障

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