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Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ23381; IRE-BP 2; Iron regulatory protein 2; iron-regulatory protein 2; iron-responsive element binding protein 2; Iron-responsive element-binding protein 2; IRP2
基因别名: ACO3; D9Ertd85e; IREB2; IRP2; IRP2AD
UniProt ID: (Human) P48200, (Rat) Q62751, (Mouse) Q811J3
Entrez Gene ID: (Human) 3658, (Rat) 64831, (Mouse) 64602