Search
Invitrogen
IRF1 Recombinant Rabbit Monoclonal Antibody (SR44-08)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
MA5-31996
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SR44-08
抗原
Recombinant protein within Human IRF1 aa 86-325.
偶联物
形式
Liquid
浓度
1.06 mg/mL
规格
106 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Interferon regulatory factor 1; IRF-1; IRF1; translated product has a 124 residue deletion in the C-terminal compared to NP002189.1; translated product has a 158 residue deletion in the C-terminal compared to NP002189.1; unnamed protein product
基因别名: AU020929; IMD117; IRF-1; IRF1; MAR
UniProt ID: (Human) P10914, (Mouse) P15314, (Rat) P23570
Entrez Gene ID: (Human) 3659, (Mouse) 16362, (Rat) 24508
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
immune system process
regulation of adaptive immune response
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
negative regulation of cell proliferation
regulation of gene expression
positive regulation of type I interferon production
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
regulation of MyD88-dependent toll-like receptor signaling pathway
cellular response to interferon-beta
CD8-positive, alpha-beta T cell differentiation
innate immune response
regulation of innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of cell cycle
interferon-gamma-mediated signaling pathway
cellular response to mechanical stimulus
regulation of CD8-positive, alpha-beta T cell proliferation
transcription, DNA-templated
cell cycle arrest
I-kappaB kinase/NF-kappaB signaling
positive regulation of cell death
positive regulation of natural killer cell differentiation
negative regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of interleukin-12 biosynthetic process
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
response to growth hormone
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
female pregnancy
response to heat
regulation of cell proliferation
cellular response to retinoic acid
cellular response to dsRNA
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
