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Bethyl Laboratories
IRF2 Polyclonal Antibody
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FIGURE: 1 / 1
IRF2 Antibody (A303-379A) in IP
Detection of human IRF2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from human erythroleukemia (HEL) cells. Antibodies: Affinity purified rabbit anti-IRF2 antibody (Product # A303-379A) used for IP at 6 µg/mg lysate. IRF2 was also immunoprecipitated by rabbit anti-IRF2 antibodies A303-380A, A303-381A, and A303-382A, which recognize disparate epitopes. For blotting immunoprecipitated IRF2, A303-380A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 seconds.
Product Details
A303-379A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 100 and 150 of mouse Interferon Regulatory Factor 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
IRF2 belongs to the interferon regulatory factor family. IRF2 regulates the transcription regulation important to cell proliferation as well as immune responses by binding to the upstream regulatory region of type I IFN and IFNinducible MHC class I genes (the interferon consensus sequence (ICS)) and repression of those genes. However, IRF2 also functions as a transcriptional activator of histone H4 by interactions with NF-kappa B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686F0244; Interferon regulatory factor 2; IRF-2; IRF2; OTTHUMP00000218576; OTTHUMP00000218580; unnamed protein product
Gene Aliases: IRF-2; IRF2
UniProt ID: (Human) P14316
Entrez Gene ID: (Human) 3660
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
immune system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell proliferation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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