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Rockland
IRGC Polyclonal Antibody
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FIGURE: 1 / 3
IRGC Antibody (600-401-CA7) in ICC/IF
Immunocytochemistry of IRGC antibody. Tissue: A20 cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: IRGC antibody at 2.5 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: IRGC is a membrane protein. Staining: IRGC as precipitated brown signal with blue counterstain.
Product Details
600-401-CA7
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-IRGC antibody was prepared from whole rabbit serum produced by repeated immunizations with a 12 amino acid synthetic peptide near the C-terminus of human IRGC.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cinema 1; Immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon inducible GTPase family member 5; interferon-gamma-inducible GTPase IFGGE protein; Interferon-inducible GTPase 5
Gene Aliases: CINEMA; F630044M05Rik; Gm1102; Gm474; IFGGE; IIGP5; IRGC; IRGC1; R30953_1; RGD1311107
UniProt ID: (Human) Q6NXR0, (Rat) Q6AYF9
Entrez Gene ID: (Human) 56269, (Rat) 308428, (Mouse) 210145
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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