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Antibodies Inc
IRSp53/BAIAP2 Monoclonal Antibody (L117/1), FL490
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产品信息
75-449-FL490
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
L117/1
抗原
Fusion protein amino acids 1-250 (N-terminus) of human BAIAP2 (accession number Q9UQB8) produced recombinantly in E. Coli.
偶联物
激发/发射光谱
491/515 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; insulin receptor substrate 53; insulin receptor substrate of 53 kDa; insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate; Insulin receptor tyrosine kinase substrate protein p53; IRS-58; IRSp53; IRSp53/58
基因别名: BAIAP2; BAP2; FLAF3; IRSP53; R75030
UniProt ID: (Human) Q9UQB8, (Mouse) Q8BKX1, (Rat) Q6GMN2
Entrez Gene ID: (Human) 10458, (Mouse) 108100, (Rat) 117542
plasma membrane organization
axonogenesis
insulin receptor signaling pathway
regulation of cell shape
response to bacterium
dendrite development
positive regulation of actin filament polymerization
regulation of actin cytoskeleton organization
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
regulation of synaptic plasticity
actin filament bundle assembly
actin crosslink formation
positive regulation of dendritic spine morphogenesis
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
Rho protein signal transduction
