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Abnova
ISL2 Monoclonal Antibody (1D9)
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产品信息
H00064843-M03
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
1D9
抗原
ISL2 (NP_665804.1, 261 a.a. approximately 358 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN SMVPSPVE
靶标信息
ISL LIM Homeobox 2 (ISL2) is a gene located on chromosome 15q23 that encodes a transcription factor belonging to the LIM-homeodomain family. These transcription factors play critical roles in the regulation of gene expression during embryonic development, particularly in the differentiation and maintenance of neuronal and pancreatic cell lineages. ISL2 is specifically involved in the development of the nervous system, where it contributes to motor neuron differentiation and connectivity, as well as in the development of certain retinal structures. The protein functions by binding to specific DNA sequences, thereby influencing the transcription of target genes essential for cellular differentiation and identity. Although less studied than its paralog ISL1, ISL2's expression and roles in developmental pathways are crucial for proper organogenesis and tissue specification. Dysregulation of ISL2 has potential implications in developmental disorders and diseases involving neural and pancreatic tissues. Ongoing research aims to further elucidate its functions and potential as a therapeutic target in developmental biology and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Insulin gene enhancer protein ISL-2; ISL2 transcription factor, LIM/homeodomain, (islet-2); Islet-2
基因别名: ISL2
UniProt ID: (Human) Q96A47
Entrez Gene ID: (Human) 64843
