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Invitrogen
ITGA5/ITGB1 Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-59619
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term BMS patent anti-Integrin alpha 5 beta 1.
靶标信息
The ITGA5 and ITGB1 genes encode the alpha-5 and beta-1 subunits of integrin receptors, respectively. These integrins are transmembrane receptors that mediate cell adhesion and signaling between the extracellular matrix (ECM) and the cell interior. ITGA5, located on chromosome 12q13, binds with ITGB1, located on chromosome 10p11, to form the alpha 5 beta 1 integrin heterodimer, which specifically interacts with fibronectin, facilitating cell adhesion, migration, proliferation, and survival. Alterations in the expression and functional activity of ITGA5 and ITGB1 have been implicated in various cancers, such as gliomas and non-small cell lung cancer (NSCLC), where they play vital roles in tumor progression, metastasis, and the tumor immune microenvironment. Understanding the roles of these integrins can aid in the development of prognostic biomarkers and therapeutic targets for cancer treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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