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Invitrogen
ITGB1 Polyclonal Antibody
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ITGB1 Antibody (PA5-78028) in ICC/IF
Immunofluorescence analysis of ITGB1 was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with ITGB1 Polyclonal Antibody (Product # PA5-78028) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32... View More
产品信息
PA5-78028
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Mouse,
Rat
已发表种属
C. elegans,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide encompassing a sequence within the Intracellular domain of human Integrin beta 1/CD29. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.51 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: A431, HeLa, U87-MG, SK-N-SH, IMR32, SK-N-AS, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat-2, J82
Predicted Reactivity: Xenopus laevis (100%), Cat (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Beta OL; Beta oligodendroglia; CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; integrin beta 1 (fibronectin receptor beta); Integrin beta-1; Integrin beta1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; very late activation protein, beta polypeptide; VLA-4 subunit beta
基因别名: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; FNRB; Gm9863; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB
UniProt ID: (Human) P05556, (Mouse) P09055, (Rat) P49134
Entrez Gene ID: (Human) 3688, (Dog) 477956, (Mouse) 16412, (Rat) 24511
virus receptor activity
glycoprotein binding
fibronectin binding
protease binding
actin binding
integrin binding
protein binding
coreceptor activity
protein kinase binding
protein domain specific binding
C-X3-C chemokine binding
protein complex binding
peptide binding
laminin binding
metal ion binding
protein heterodimerization activity
cell adhesion molecule binding
alpha-actinin binding
collagen binding involved in cell-matrix adhesion
cadherin binding involved in cell-cell adhesion
receptor activity
receptor binding
collagen binding
kinase binding
integrin
G1/S transition of mitotic cell cycle
in utero embryonic development
cell fate specification
tissue homeostasis
cell migration involved in sprouting angiogenesis
cellular calcium ion homeostasis
cellular defense response
homophilic cell adhesion via plasma membrane adhesion molecules
leukocyte cell-cell adhesion
cell-matrix adhesion
calcium-independent cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
germ cell migration
visual learning
regulation of collagen catabolic process
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
response to activity
cell migration
formation of radial glial scaffolds
B cell differentiation
extracellular matrix organization
positive regulation of cell migration
negative regulation of cell projection organization
cell-substrate adhesion
receptor internalization
protein transport within lipid bilayer
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
response to gonadotropin
negative regulation of Rho protein signal transduction
response to drug
positive regulation of apoptotic process
stress fiber assembly
positive regulation of MAPK cascade
positive regulation of GTPase activity
sarcomere organization
negative regulation of neuron differentiation
positive regulation of endocytosis
viral entry into host cell
mesodermal cell differentiation
axon extension
dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
regulation of immune response
leukocyte migration
leukocyte tethering or rolling
regulation of cell cycle
cardiac muscle cell differentiation
maternal process involved in female pregnancy
bicellular tight junction assembly
cellular response to mechanical stimulus
cellular response to vitamin D
cellular response to low-density lipoprotein particle stimulus
cellular response to ionizing radiation
positive regulation of establishment of protein localization to plasma membrane
negative regulation of anoikis
cell adhesion
neuron projection development
negative regulation of cell differentiation
positive regulation of neuron differentiation
cardiac muscle tissue development
response to nutrient levels
response to transforming growth factor beta
