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Invitrogen
ITGB5 Recombinant Rabbit Monoclonal Antibody (PSH11-53)
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图: 1 / 7
ITGB5 Antibody (MA562921) in ICC/IF
Immunofluorescence analysis of ITGB5 was performed using PANC-1 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with ITGB5 Recombinant Rabbit Monoclonal Antibody (PSH11-53) (Product # MA562921) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790, 1:2,... View More
产品信息
MA562921
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH11-53
抗原
Recombinant protein within human Integrin beta 5 aa 1-719.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: A549
Tissue Specificity: Low tissue specificity
Subcellular Location: Cell membrane.
Sequence Similarities: 91% Mouse,Rat
Predicted band size: 37 kDa.
靶标信息
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD61; FLJ26658; GP3A; GPIIIa; Integrin beta-5; integrin beta-5 subunit; integrin beta-5 subunit precursor; testis secretory sperm-binding protein Li 217p; unnamed protein product
基因别名: ITGB5
UniProt ID: (Human) P18084
Entrez Gene ID: (Human) 3693
formation of primary germ layer
cell adhesion
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
cell migration
cell adhesion mediated by integrin
wound healing, spreading of epidermal cells
endodermal cell differentiation
stress fiber assembly
viral entry into host cell
epithelial cell-cell adhesion
cell-cell adhesion
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